- Title
- Protein chimerization: a new frontier for engineering protein therapeutics with improved pharmacokinetics
- Creator
- Satvik Iyengar, A. R.; Gupta, Shreya; Jawalekar, Snehal; Pande, Abhay H.
- Relation
- Journal of Pharmacology and Experimental Therapeutics Vol. 370, Issue 3, p. 703-714
- Publisher Link
- http://dx.doi.org/10.1124/jpet.119.257063
- Publisher
- Amercian Society for Pharmacology and Experimental Therapeutics
- Resource Type
- journal article
- Date
- 2019
- Description
- With the advancement of medicine, the utility of protein therapeutics is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which include their subpar pharmacokinetics. In this study, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. We have discussed various aspects of protein therapeutics aiming at their mechanism of clearance and various approaches used to increase their short circulatory half-life with principal focus on the concept of chimerization. Furthermore, we have comprehensively reviewed various components of chimera, such as half-life extension partners and linkers, their shortcomings, and prospective work to be undertaken for developing effective chimeric protein therapeutics.
- Subject
- protein therapeutics; pharmacokinetics; protein; chimerization
- Identifier
- http://hdl.handle.net/1959.13/1442652
- Identifier
- uon:41754
- Identifier
- ISSN:0022-3565
- Language
- eng
- Reviewed
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